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While short-term glucocorticoid steroid treatment for DMD is beneficial, the effects of long-term treatment on muscle strength and function are not well understoodat this point. The purpose of this study was to determine the effect of 1 month of glucocorticoid treatment on strength gains in men with DMD (n = 22) and to assess changes in strength and function in the knee using the Maximal isokinetic squat, squat-to-bench press, and isokinetic elbow flexion and extension exercises at the time of initial assessment and over 8 weeks (10). Subjects were randomly assigned to treatment groups; placebo, a short-term treatment consisting of 15 days of glucocorticoid (300 mg/day), 2 weeks of glucocorticoid (600 mg/day), 3 weeks of glucocorticoid (800 mg/day), 4 weeks of glucocorticoid (1,000 mg/day), 6 weeks of glucocorticoid (2,200 mg/day), or 8 weeks of glucocorticoid (3,200 mg/day). There were no significant differences in baseline strength between the 5 groups. Strength gains were 2.9 kg (p = .005) and 4.8 kg (p = .03) in the 2-week and 8-week treatment groups, respectively. At 1 month after treatment, there was a significant increase in strength (2.7 kg) and function (4.8 kg) gains (n = 21) in the 8-week treatment Group (mean ± SEM, 2.5 ± 1.8 kg and 4.9 ± 2.6 kg, p < .001 and p < .001, respectively) and no statistically significant differences were seen between the placebo, short-term treatment, or 2-week treatment Groups as determined by t test (2-way repeated measures ANOVA with Group a factor). The difference between a group receiving placebo and placebo + 1 week treatment was not significant in any of the measures (p < .005 and p = .35, respectively). There were only one drop out in the placebo group for any of the strength measures because either the subject withdrew during the study or refused to submit to a randomization process or the study had to be terminated because of incomplete analysis of urine samples. CONCLUSIONS: Overall, these results demonstrated that short-term glucocorticoid treatment for DMD resulted in improved strength improvements and improved function over several weeks of treatment. This evidence was supported by improvements in strength at the 1-month time point in the short-term treatment (vs placebo + 1 week treatment Similar articles: